美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Leuprolide Mesylate	Emulsion			Develop a method to characterize in vitro release			2023/10/06
Levacetylleucine	For Suspension	II (Paddle)	50	0.1 N HCl	900	5, 10, 15, 30 and 45	2026/01/28
Levetiracetam	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Levetiracetam	Tablet, for Suspension	II (Paddle)	50	Phosphate Buffer, pH 6.8 (degas)	900	2.5, 5, 10, 15 and 20	2017/03/02
Levetiracetam (1 g and 1.5 g)	Tablet (Extended Release)	III (Reciprocating Cylinder)	15 dips/min	Sodium acetate buffer, pH 4.5	900	1, 2, 4, 6, 8, 10 and 12 hours	2024/11/01
Levetiracetam (500 mg and 750 mg)	Tablet (Extended Release)	I (Basket)	100	0.05 M Phosphate Buffer, pH 6.0	900	1, 2, 4, 6, 8 and 12 hours	2009/04/02
Levocarnitine	Tablet			Develop a dissolution method			2024/01/03
Levocetirizine Dihydrochloride	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Levofloxacin	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Levoketoconazole	Tablet	II (Paddle)	50	0.05 N HCl	900	10, 20, 30, 45 and 60	2025/06/23
Levomilnacipran HCl	Capsule (Extended Release)			Develop a dissolution method			2023/09/15
Levonorgestrel	Tablet	II (Paddle)	75	0.1 N HCl with 0.1% SLS	1000	10, 20, 30, 45, 60 and 90	2004/02/05
Levonorgestrel	Intrauterine Device			Develop a method to characterize in vitro release			2014/02/14
Levorphanol Tartrate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2021/04/22
Levothyroxine Sodium	Capsule	I (Basket)	100	0.01 N HCl, pH 2.05	500	5, 10, 15, 20, 30, 45 and 60	2026/05/22
Levothyroxine Sodium	Tablet			Refer to USP			2007/07/25
Lidocaine	Patch	Paddle over Disk (Apparatus 5)	50	Acetic acid/sodium acetate buffer, pH 4.0 at 32ºC	500	10, 20, 30, 60, 120 and 180	2007/01/03
Lidocaine	System	VI (Cylinder)	50	Diluted McIlvaine buffer solution, pH 5.5	900	60, 120, 180, 360 and 1440	2026/05/22
Linaclotide	Capsule	I (Basket)	50	50 mM Phosphate Buffer, pH 4.5	500	5, 10, 15, 20 and 30	2015/12/24
Linagliptin	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02