美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Boceprevir	Capsule	II (Paddle) with sinker	50	50 mM phosphate buffer, pH 6.8 with 0.1% sodium dodecyl sulfate	900	10, 20, 30, 45, 60 and 75	2013/01/31
Bosentan	Tablet			Develop a dissolution method			2023/09/15
Bosentan	Tablet (For Suspension)	II (Paddle)	75	0.1 N HCl with 0.5% sodium dodecyl sulfate (SDS), pH 1.1	900	5, 10, 15, 20 and 30	2017/11/16
Bosutinib Monohydrate	Capsule	II (Paddle)	50	0.1 N HCl	900	5, 10, 15, 20, 30, 45 and 60	2026/05/22
Bosutinib Monohydrate	Tablet	II (Paddle)	50	0.1 N HCl	900	10, 15, 20, 30 and 45	2015/06/25
Brensocatib	Tablet			Refer to FDA's Dissolution Guidance, 2018			2026/05/22
Brexpiprazole	Tablet	II (Paddle)	50	0.05 M Acetate buffer, pH 4.3	900	10, 15, 20, 30 and 45	2016/10/20
Brigatinib	Tablet	II (Paddle)	70	50 mM Potassium Phosphate Buffer, pH 7.2	900	5, 10, 15, 20, 30 and 45	2017/11/02
Brimonidine Tartrate/Brinzolamide	Ophthalmic Suspension			Develop a method to characterize in vitro release			2015/01/15
Brincidofovir	Tablet	I (Basket)	50	50 mM sodium phosphate buffer, pH 6.4 + 0.3% SDS	900	5, 10, 15, 20, 30, 45, 60, 75 and 90	2023/07/07
Brincidofovir	Suspension	II (Paddle)	50	0.05 M Sodium Phosphate Monobasic, Monohydrate Buffer, pH 6.4 + 0.05% Tween 80	900	5, 10, 15, 20, 30, 45, 60, 75 and 90	2023/07/07
Brinzolamide	Ophthalmic Suspension			Develop a method to characterize in vitro release			2011/09/01
Brivaracetam	Tablet	II (Paddle	50	Phosphate Buffer, pH 6.4	2.5 and 5 mg tablets: 500 mL; 10, 25, 50, 75 and 100 mg tablets: 900 mL	5, 10, 15, 20 and 30	2016/07/28
Bromocriptine Mesylate	Capsule	I (Basket)	75	0.1 N HCl	500	5, 10, 15, 20, 30, 45 and 60	2026/05/22
Bromocriptine Mesylate	Tablet			Refer to USP			2007/07/25
Budesonide	Tablet (Extended Release)	II (Paddle)	100	Acid Stage: 0.1 M HCl containing 0.5% Macrogol Cetostearyl Ether; Buffer Stage: pH 7.2 phosphate buffer containing 0.5% Macrogol Cetostearyl Ether.	Acid Stage: 500 mL ; Buffer Stage: 1000 mL	Acid Stage: 2 hours; Buffer Stage: 1, 2, 4, 6, 8 and 10 hours	2015/04/02
Budesonide	Capsule	II (Paddle) with sinker	75	Acid stage: 0.1 N HCl; Buffer stage: Phosphate Buffer, pH 7.5	Acid stage: 1000; Buffer stage: 1000	Acid stage: 2 hours; Buffer stage: 0.25, 0.5, 1, 2, 4, 6 and 8 hours	2015/02/25
Budesonide	Suspension	II (Paddle)	50	0.25% SDS in 0.009 N HCl	500	5, 10, 15, 20, 30, 45 and 60	2026/01/28
Bumetanide	Tablet			Develop a dissolution method			2024/01/03
Bupivacaine	Solution (Extended Release), Infiltration	II (Paddle)	50	0.025 M Sodium Phosphate Buffer with 0.03% Sodium Dodecyl Sulfate (SDS), pH 7.4	900	1, 2, 4, 8, 12, 16, 24, 36 and 48 hours	2022/07/07