Triflusal
Structural Formula Vector Image
Title: Triflusal
CAS Registry Number: 322-79-2
CAS Name: 2-(Acetyloxy)-4-(trifluoromethyl)benzoic acid
Additional Names: a,a,a-trifluoro-2,4-cresotic acid acetate; acetyl-4-trifluoromethylsalicylic acid
Manufacturers' Codes: UR-1501
Trademarks: Disgren (Uriach)
Molecular Formula: C10H7F3O4
Molecular Weight: 248.16
Percent Composition: C 48.40%, H 2.84%, F 22.97%, O 25.79%
Literature References: Analog of aspirin, q.v.; inhibits platelet aggregation. Prepn of free acid: M. Hauptschein, US 3019253 (1962 to Pennsalt). Inhibition of platelet aggregation in man and rat: J. Garcia-Rafanell, J. Morell, Therapie 32, 337 (1977). Effect on blood coagulation: M. Rutllant et al., Curr. Ther. Res. 22, 510 (1977). Pharmacokinetics: V. Rimbau et al., Arch. Farmacol. Toxicol. 7, 11 (1981). Clinical studies: R. M. Masso et al., Curr. Ther. Res. 25, 791 (1979); E. Sala-Planell et al., Angiologia 33, 71 (1981).
Properties: White cryst solid from petr ether/ether, mp 120-122° (upon slow heating); 110-112° (upon quick heating). Misc with ethanol. Practically insol in water.
Melting point: mp 120-122° (upon slow heating); 110-112° (upon quick heating)
Therap-Cat: Antithrombotic.
Keywords: Antithrombotic.

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