Sulfaperine
Structural Formula Vector Image
Title: Sulfaperine
CAS Registry Number: 599-88-2
CAS Name: 4-Amino-N-(5-methyl-2-pyrimidinyl)benzenesulfonamide
Additional Names: N1-(5-methyl-2-pyrimidinyl)sulfanilamide; 5-methyl-2-sulfanilamidopyrimidine; 2-sulfanilamido-5-methylpyrimidine; isosulfamerazine; 5-methylsulfadiazine
Trademarks: Pallidin (Merck KGaA); Retardon (Chassot); Rexulfa (Medici); Sintosulfa (Afi); Sulfatreis (Ecobi)
Molecular Formula: C11H12N4O2S
Molecular Weight: 264.30
Percent Composition: C 49.99%, H 4.58%, N 21.20%, O 12.11%, S 12.13%
Literature References: Prepd by condensing 2-amino-5-methylpyrimidine with acetylsulfanilyl chloride followed by hydrolysis of the acetyl group with NaOH: Sprague, US 2407966 (1946 to Sharp & Dohme).
Properties: Minute, cream-colored crystals, mp 262-263°. Very sparingly sol in water, ethanol; ~40 mg/100 ml H2O at pH 5.5. Sol in aq solns of acids and alkalies. Forms a water-sol sodium salt.
Melting point: mp 262-263°
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Sulfonamides.

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