Roxithromycin
Structural Formula Vector Image
Title: Roxithromycin
CAS Registry Number: 80214-83-1
CAS Name: Erythromycin 9-[O-[(2-methoxyethoxy)methyl]oxime]
Additional Names: oxacyclotetradecane erythromycin deriv; 9-(2¢,5¢-dioxahexyloxyimino)erythromycin
Manufacturers' Codes: RU-28965; RU-965
Trademarks: Assoral (Glaxo); Claramid (Jouveinal); Forilin (Novo); Overal (Lusofarmaco); Rossitrol (Corvi); Rotramin (Glaxo-Allen); Rulid (Hoechst); Surlid (HMR)
Molecular Formula: C41H76N2O15
Molecular Weight: 837.05
Percent Composition: C 58.83%, H 9.15%, N 3.35%, O 28.67%
Literature References: Semisynthetic erythromycin derivative. Prepn: S. Gouin d¢Ambrieres et al., FR 2473525; eidem, US 4349545 (1981, 1982 both to Roussel-UCLAF). In vitro antibacterial spectrum: R. N. Jones et al., Antimicrob. Agents Chemother. 24, 209 (1983); Y. J. Drabu et al., Drugs Exp. Clin. Res. 13, 201 (1987). Antiprotozoal activity in mice: B. J. Luft, Eur. J. Clin. Microbiol. 6, 479 (1987); H. R. Chang, J.-C. R. Pechere, Antimicrob. Agents Chemother. 31, 1147 (1987). Pharmacokinetics: R. Wise et al., ibid. 1051. Bioassay in biological fluids: A. L. Barry, R. R. Packer, Eur. J. Clin. Microbiol. 5, 536 (1986). Clinical evaluations in respiratory tract infections: J. M. Lachat et al., Schweiz. Med. Wochenschr. 116, 1739 (1986); C. Grassi et al., Chemioterapia 6, 41 (1987). Series of articles on antimicrobial activity, pharmacokinetics and clinical efficacy: J. Antimicrob. Chemother. 20, Suppl. B, 1-185 (1987).
Properties: [a]D25 -77.5 ±2° (c = 0.45 in chloroform).
Optical Rotation: [a]D25 -77.5 ±2° (c = 0.45 in chloroform)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Macrolides.

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