Pempidine
Structural Formula Vector Image
Title: Pempidine
CAS Registry Number: 79-55-0
CAS Name: 1,2,2,6,6-Pentamethylpiperidine
Molecular Formula: C10H21N
Molecular Weight: 155.28
Percent Composition: C 77.35%, H 13.63%, N 9.02%
Literature References: Ganglion blocking agent. Prepn by methylation of 2,2,6,6-tetramethylpiperidine: Leonard, Hauck, J. Am. Chem. Soc. 79, 5289 (1957); Hall, ibid. 5447. Description: Spinks, Young, Nature 181, 1397 (1958); Lee et al., ibid. 1717.
Properties: Liquid. pK at 30° = 11.25. Extremely basic reaction for a tertiary amine. bp760 147°. nD21 1.4550.
Boiling point: bp760 147°
pKa: pK at 30° = 11.25
Index of refraction: nD21 1.4550
 
Derivative Type: p-Toluenesulfonate
Molecular Formula: C17H19NO3S
Molecular Weight: 317.40
Percent Composition: C 64.33%, H 6.03%, N 4.41%, O 15.12%, S 10.10%
Properties: Crystals from ethyl acetate + ethanol, mp 162-163°.
Melting point: mp 162-163°
 
Derivative Type: Tartrate
CAS Registry Number: 546-48-5
Manufacturers' Codes: M & B 4486
Trademarks: Pempidil (Farmigea); Pempiten (I.G.I.); Perolysen (M & B); Tenormal (Zeneca); Tensinol (Farmaroma); Tensoral (Diana)
Molecular Formula: C10H21N.C4H6O6
Molecular Weight: 305.37
Percent Composition: C 55.06%, H 8.91%, N 4.59%, O 31.44%
Properties: Crystals, mp 160°. Sol in alcohol, moderately sol in water.
Melting point: mp 160°
 
Derivative Type: Hydrochloride
Molecular Formula: C10H21N.HCl
Molecular Weight: 191.74
Percent Composition: C 62.64%, H 11.56%, N 7.31%, Cl 18.49%
Properties: Crystals, sol in water, alc.
 
Therap-Cat: Tartrate as antihypertensive.
Keywords: Antihypertensive.

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