Structural Formula Vector Image
Title: Nithiazide
CAS Registry Number: 139-94-6
CAS Name: N-Ethyl-N¢-(5-nitro-2-thiazolyl)urea
Trademarks: Hepzide (Merck & Co.)
Molecular Formula: C6H8N4O3S
Molecular Weight: 216.22
Percent Composition: C 33.33%, H 3.73%, N 25.91%, O 22.20%, S 14.83%
Literature References: Prepd by the condensation of ethyl isocyanate with 2-amino-5-nitrothiazole in toluene: Cuckler et al., Proc. Soc. Exp. Biol. Med. 92, 483 (1956); O'Neill et al., US 2755285 (1956 to Merck & Co.).
Properties: Crystals, dec 228°. pKa 7.3. Practically insol in water: 3 mg/100 ml.
pKa: pKa 7.3
Derivative Type: Sodium salt
Properties: Orange plates. Soly in water: 8 g/100 ml. Aq solns are alkaline and unstable.
Derivative Type: Potassium salt
Properties: Crystals. Soly in water: 3 g/l00 ml. Aq solns are more stable than those of the Na salt.
Therap-Cat-Vet: Antiprotozoal.

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