Iomeprol
Structural Formula Vector Image
Title: Iomeprol
CAS Registry Number: 78649-41-9
CAS Name: N,N¢-Bis(2,3-dihydroxypropyl)-5-[(hydroxyacetyl)methylamino]-2,4,6-triiodo-1,3-benzenedicarboxamide
Additional Names: N,N¢-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(N-methylglycolamido)isophthalamide
Manufacturers' Codes: B-16880
Trademarks: Imeron (Bracco); Iomeron (Bracco)
Molecular Formula: C17H22I3N3O8
Molecular Weight: 777.09
Percent Composition: C 26.28%, H 2.85%, I 48.99%, N 5.41%, O 16.47%
Literature References: Nonionic x-ray contrast media. Prepn: E. Felder, D. Pitrè, EP 026281; eidem, US 4352788 (1981, 1982 both to Bracco). HPLC determn in plasma and urine: V. Lorusso et al., J. Chromatogr. 525, 401 (1990). Series of articles on properties, pharmacology, pharmacokinetics and clinical experience in angiography and urography: Eur. J. Radiol. 18, Suppl. 1, S1-S124 (1994). Toxicology study: A. Morisetti et al., ibid. S21.
Properties: Crystalline powder, mp 285-291° (dec). Extremely sol in water, very sol in methanol, poorly sol in ethanol. Practically insol in chloroform. Aqueous soln of 150 mg I/ml: d420 1.166, d437 1.161; osmolality (37°) 0.27 osmol/kg H2O; viscosity at 20° (mPa.s) 1.9, at 37° 1.3; nD20 1.3828. Aqueous soln of 300 mg I/ml: d420 1.334, d437 1.329; osmolality (37°) 0.52 osmol/kg H2O; viscosity at 20° (mPa.s) 8.4, at 37° 4.8; nD20 1.4327. Aqueous soln of 400 mg I/ml: d420 1.446, d437 1.441; osmolality (37°) 0.72 osmol/kg H2O; viscosity at 20° (mPa.s) 28.9, at 37° 13.9; nD20 1.4660. LD50 (400 mgI/ml soln) i.v. in mice, rats (gI/kg): 19.9, 14.5; LD50 (370 mgI/ml soln) i.v. in dogs (gI/kg): >12.5 (Morisetti).
Melting point: mp 285-291° (dec)
Index of refraction: nD20 1.3828; nD20 1.4327; nD20 1.4660
Density: d420 1.166; d437 1.161; d420 1.334; d437 1.329; d420 1.446; d437 1.441
Toxicity data: LD50 (400 mgI/ml soln) i.v. in mice, rats (gI/kg): 19.9, 14.5; LD50 (370 mgI/ml soln) i.v. in dogs (gI/kg): >12.5 (Morisetti)
Therap-Cat: Diagnostic aid (radiopaque medium).
Keywords: Diagnostic Aid (Radiopaque Medium).

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