Gadobutrol
Structural Formula Vector Image
Title: Gadobutrol
CAS Registry Number: 138071-82-6
CAS Name: [10-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)-N1,N4,N7,N10,O1,O4,O7]gadolinium
Additional Names: Gd-DO3A-butrol
Trademarks: Gadovist (Schering AG)
Molecular Formula: C18H31GdN4O9
Molecular Weight: 604.71
Percent Composition: C 35.75%, H 5.17%, Gd 26.00%, N 9.27%, O 23.81%
Literature References: Neutral, macrocyclic gadolinium chelate. Prepn: J. Platzek et al., EP 448191 (1991 to Schering AG). Physicochemical properties and in vivo imaging studies: H. Vogler et al., Eur. J. Radiol. 21, 1 (1995). Clinical pharmacokinetics: T. Staks et al., Invest. Radiol. 29, 709 (1994). Clinical evaluation of diagnostic use for cerebral metastases: T. J. Vogl et al., Radiologe 35, 508 (1995); for glioblastomas: M. Hartmann et al., Fortschr. Röntgenstr. 164, 119 (1996).
Properties: Hydrophilic. Osmolality (osmol/kg): 0.57 (0.5 mol/l); 1.39 (1 mol/l). Viscosity (cP): 1.43 (0.5 mol/l); 3.7 (1 mol/l). Partition coefficient (butanol/water): 0.006. LD50 i.v. in mice: 23 mmol/kg (Vogler).
Log P: Partition coefficient (butanol/water): 0.006
Toxicity data: LD50 i.v. in mice: 23 mmol/kg (Vogler)
Therap-Cat: Diagnostic aid (MRI contrast agent).
Keywords: Diagnostic Aid (MRI Contrast Agent).

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