Chlorphentermine
Structural Formula Vector Image
Title: Chlorphentermine
CAS Registry Number: 461-78-9
CAS Name: 4-Chloro-a,a-dimethylbenzeneethanamine
Additional Names: 4-chloro-a,a-dimethylphenethylamine; a,a-dimethyl-p-chlorophenethylamine; 1-(p-chlorophenyl)-2-methyl-2-propylamine; 1-(p-chlorophenyl)-2-methyl-2-aminopropane; clorfentermina
Trademarks: Lucofen (Lundbeck); Teramine (Darby)
Molecular Formula: C10H14ClN
Molecular Weight: 183.68
Percent Composition: C 65.39%, H 7.68%, Cl 19.30%, N 7.63%
Literature References: Prepn: Bachman et al., J. Am. Chem. Soc. 76, 3972 (1954); Ferrari, Farmaco Ed. Sci. 15, 337 (1960); FR M1299 and FR 1296132 (1962 to Simes), C.A. 58, 4467e, 3352g (1963); GB 90633l (1962 to Kefalas), C.A. 58, 6654c (1963). Pharmacology: Jun et al., Can. J. Pharm. Sci. 4, 27 (1969); Ciborska et al., Acta Pol. Pharm. 26, 595 (1969); Moeller-Nielsen, Dubnick, Proc. Int. Symp. Amphetamines Relat. Compounds 1969, E. Costa, Ed. (Raven Press, New York, 1970) pp 63-73.
Properties: Liquid. bp2 100-102°.
Boiling point: bp2 100-102°
 
Derivative Type: Hydrochloride
CAS Registry Number: 151-06-4
Trademarks: Pre-Sate (Warner-Lambert)
Molecular Formula: C10H14ClN.HCl
Molecular Weight: 220.14
Percent Composition: C 54.56%, H 6.87%, Cl 32.21%, N 6.36%
Properties: Crystals from alcohol + ether, mp 234°. Soly in water: >20%. pH of 1% aq soln ~5.5. LD50 in mice (mg/kg): 270 orally; 267 s.c. (Ciborska).
Melting point: mp 234°
Toxicity data: LD50 in mice (mg/kg): 270 orally; 267 s.c. (Ciborska)
 
NOTE: This is a controlled substance (stimulant): 21 CFR, 1308.13.
Therap-Cat: Anorexic.
Keywords: Anorexic; CNS Stimulant.

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