Structural Formula Vector Image
Title: Bentiromide
CAS Registry Number: 37106-97-1
CAS Name: 4-[[(2S)-2-(Benzoylamino)-3-(4-hydroxyphenyl)-1-oxopropyl]amino]benzoic acid
Additional Names: (S)-p-(a-benzamido-p-hydroxyhydrocinnamamido)benzoic acid; N-benzoyl-L-tyrosyl-p-aminobenzoic acid; BTPABA
Manufacturers' Codes: E-2663
Trademarks: Chymex (Savage); PFT Roche (Roche)
Molecular Formula: C23H20N2O5
Molecular Weight: 404.42
Percent Composition: C 68.31%, H 4.98%, N 6.93%, O 19.78%
Literature References: Synthetic chymotrypsin-labile peptide, used in diagnosis of exocrine pancreatic disease. Prepn: P. L. De Benneville, N. J. Greenberger, DE 2156835; eidem, US 3801562 (1972, 1974 both to Rohm & Haas). Synthesis, in vitro and in vivo data: P. L. De Benneville et al., J. Med. Chem. 15, 1098 (1972). Early clinical studies: K. Gyr et al., Schweiz. Med. Wochenschr. 105, 1717 (1975); W. Bornschein et al., Clin. Chim. Acta 67, 21 (1976). Pediatric study: G. Dockter et al., Eur. J. Pediatr. 135, 277 (1981). Human toxicity study, effects of renal insufficiency on pancreatic function test: C. Lang et al., J. Clin. Chem. Clin. Biochem. 18, 551 (1980).
Properties: Cryst from methanol/water, mp 240-242°. [a]D25 +72.3° (c = 1 in DMF) (US 3801562); also reported as [a]D25 +87° (c = 1 in DMF) (De Benneville).
Melting point: mp 240-242°
Optical Rotation: [a]D25 +72.3° (c = 1 in DMF) (US 3801562); [a]D25 +87° (c = 1 in DMF) (De Benneville)
Therap-Cat: Diagnostic aid (pancreatic function).
Keywords: Diagnostic Aid.

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