Structural Formula Vector Image
Title: Zinpyr
Literature References: Family of fluorescent sensors for Zn2+ in biological applications. Prepn of ZP-1: G. K. Walkup et al., J. Am. Chem. Soc. 122, 5644 (2000); and characterization of ZP-1 and ZP-2: S. C. Burdette et al., ibid. 123, 7831 (2001); of ZP-4: idem et al., ibid. 125, 1778 (2003).
Derivative Type: Zinpyr-1
CAS Registry Number: 288574-78-7
CAS Name: 4¢,5¢-Bis[[bis(2-pyridinylmethyl)amino]methyl]-2¢,7¢-dichloro-3¢,6¢-dihydroxy-spiro[isobenzofuran-1(3H),9¢-[9H]xanthen]-3-one
Additional Names: 9-(o-carboxyphenyl)-2,7-dichloro-4,5-bis[bis(2-pyridylmethyl)aminomethyl]-6-hydroxy-3-xanthanone; ZP-1
Molecular Formula: C46H36Cl2N6O5
Molecular Weight: 823.72
Percent Composition: C 67.07%, H 4.41%, Cl 8.61%, N 10.20%, O 9.71%
Properties: Salmon-pink solid, mp 185-187° (dec). pKa 2.8. Quantum yield 0.38.
Melting point: mp 185-187° (dec)
pKa: pKa 2.8
Derivative Type: Zinpyr-2
CAS Registry Number: 357916-12-2
Additional Names: 9-(o-carboxyphenyl)-4,5-bis[bis(2-pyridylmethyl)aminomethyl]-6-hydroxy-3-xanthanone; ZP-2
Molecular Formula: C46H38N6O5
Molecular Weight: 754.83
Percent Composition: C 73.19%, H 5.07%, N 11.13%, O 10.60%
Properties: Orange solid, mp 195-197° (dec). pKa 3.9. Quantum yield 0.25.
Melting point: mp 195-197° (dec)
pKa: pKa 3.9. Quantum yield 0.25
Use: Probe for measurement of cellular Zn2+.

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