Structural Formula Vector Image
Title: Xylometazoline
CAS Registry Number: 526-36-3
CAS Name: 2-[[4-(1,1-Dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-1H-imidazole
Additional Names: 2-(4-tert-butyl-2,6-dimethylbenzyl)-2-imidazoline
Molecular Formula: C16H24N2
Molecular Weight: 244.38
Percent Composition: C 78.64%, H 9.90%, N 11.46%
Literature References: a-Adrenergic agonist; topical vasoconstrictor. Prepn: Hüni, US 2868802 (1959 to Ciba). Pharmacology: S. Morimoto, H. Tanaka, Osaka-shiritsu Daigaku Igaku Zasshi 18, 211 (1969), C.A. 72, 20437n (1970). Comprehensive description: Y. Golander, W. J. DeWitte, Anal. Profiles Drug Subs. 14, 135-156 (1985). GC determn in plasma and urine: A. Sioufi et al., J. Chromatogr. 487, 81 (1989). Clinical trial in allergic rhinitis: M. Fradis et al., J. Laryngol. Otol. 101, 666 (1987); in nasal surgery: J. P. Campbell et al., Otolaryngol. Head Neck Surg. 107, 697 (1992).
Properties: mp 131-133°.
Melting point: mp 131-133°
Derivative Type: Hydrochloride
CAS Registry Number: 1218-35-5
Trademarks: Novorin (Polfa); Olynth (Pfizer); Otrivine (Novartis); Xymelin (Nycomed)
Molecular Formula: C16H24N2.HCl
Molecular Weight: 280.84
Percent Composition: C 68.43%, H 8.97%, N 9.97%, Cl 12.62%
Properties: Soly in water: up to 3%; also sol in methanol, ethanol. Practically insol in ether, benzene.
Therap-Cat: Decongestant.
Keywords: a-Adrenergic Agonist; Decongestant.

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