Trandolapril
Structural Formula Vector Image
Title: Trandolapril
CAS Registry Number: 87679-37-6
CAS Name: (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid
Additional Names: (3aR,7aS)-1-[N-[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanyl]octahydroindole-2(S)-carboxylic acid; (2S,3aR,7aS)-1-[(S)-N-[(S)-1-carboxy-3-phenylpropyl]alanyl]hexahydro-2-indolinecarboxylic acid 1-ethyl ester
Manufacturers' Codes: RU-44570
Trademarks: Mavik (Abbott); Odrik (Aventis); Gopten (Abbott)
Molecular Formula: C24H34N2O5
Molecular Weight: 430.54
Percent Composition: C 66.95%, H 7.96%, N 6.51%, O 18.58%
Literature References: Angiotensin converting enzyme (ACE) inhibitor. Prepn: H. Urbach et al., EP 84164; eidem, US 4933361 (1983, 1990 both to Hoechst). Enzyme inhibition and pharmacology: N. L. Brown et al., Eur. J. Pharmacol. 148, 79 (1988). Clinical pharmacology: F. De Ponti et al., Eur. J. Clin. Pharmacol. 40, 149 (1991). Clinical trial in prevention of death after myocardial infarction: L. Kober et al., N. Engl. J. Med. 333, 1670 (1995). Series of articles on pharmacology and clinical trials: Am. J. Hypertens. 8, 63S-74S (1995). Clinical trial in diabetic neuropathy: R. A Malik et al., Lancet 352, 1978 (1998).
Properties: Colorless, crystalline solid, mp 125°. Sol in chloroform, dichloromethane, methanol.
Melting point: mp 125°
 
Derivative Type: Diacid
CAS Registry Number: 87679-71-8
Additional Names: Trandolaprilat
Manufacturers' Codes: RU-44403
Molecular Formula: C22H30N2O5
Molecular Weight: 402.48
Percent Composition: C 65.65%, H 7.51%, N 6.96%, O 19.88%
 
Therap-Cat: Antihypertensive.
Keywords: ACE-Inhibitor; Antihypertensive; N-Carboxyalkyl (peptide/lactam) Derivatives.

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