Structural Formula Vector Image
Title: Tolmetin
CAS Registry Number: 26171-23-3
CAS Name: 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid
Additional Names: 1-methyl-5-p-toluoylpyrrole-2-acetic acid; 5-(p-toluoyl)-1-methylpyrrole-2-acetic acid
Manufacturers' Codes: McN-2559
Molecular Formula: C15H15NO3
Molecular Weight: 257.28
Percent Composition: C 70.03%, H 5.88%, N 5.44%, O 18.66%
Literature References: Prepn: Carson, FR 1574570 (1969 to McNeil Labs.), C.A. 72, 100498y (1969). Pharmacology: Carson et al., J. Med. Chem. 14, 646 (1971); S. Wong et al., J. Pharmacol. Exp. Ther. 185, 127 (1973). Review: S. Wong in Pharmacological and Biochemical Properties of Drug Substances vol. 1, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1977) pp 233-255. Review of pharmacology and therapeutic efficacy: R. N. Brogden et al., Drugs 15, 429-450 (1978).
Properties: Crystals from acetonitrile, mp 155-157° (dec).
Melting point: mp 155-157° (dec)
Derivative Type: Sodium salt dihydrate
CAS Registry Number: 64490-92-2
Manufacturers' Codes: McN-2559-21-98
Trademarks: Reutol (Errekappa); Tolectin (McNeil); Tolmene (Sigma-Tau)
Molecular Formula: C15H14NNaO3.2H2O
Molecular Weight: 315.30
Percent Composition: C 57.14%, H 5.75%, N 4.44%, Na 7.29%, O 25.37%
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives.

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