Tolciclate
Structural Formula Vector Image
Title: Tolciclate
CAS Registry Number: 50838-36-3
CAS Name: Methyl(3-methylphenyl)carbamothioic acid O-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl) ester
Additional Names: O-(1,4-methano-1,2,3,4-tetrahydro-6-naphthyl)-N-methyl-N-(m-tolyl)thiocarbamate
Manufacturers' Codes: KC-9147
Trademarks: Fungifos (S & K Pharma); Kilmicen (Farmitalia); Tolmicen (Farmitalia)
Molecular Formula: C20H21NOS
Molecular Weight: 323.45
Percent Composition: C 74.27%, H 6.54%, N 4.33%, O 4.95%, S 9.91%
Literature References: Topical antimycotic agent with high liposolubility. Prepn: P. Melloni et al., DE 2313845 corresp to US 3855263 (1973, 1974 both to Carlo Erba). In vitro and in vivo study: I. deCarneri et al., Arzneim.-Forsch. 26, 769 (1976). Antimycotic studies: A. Bianchi et al., Antimicrob. Agents Chemother. 12, 429 (1977). Clinical studies in dermatomycosis: L. C. Cucé et al., J. Int. Med. Res. 8, 144 (1980); C. Intini et al., Pharmatherapeutica 2, 439 (1980).
Properties: White cryst powder from isopropanol, mp 92-94°. Practically insol in water. Soly (mg/ml): 14.9 in n-hexane; 23.9 in n-octanol. LD50 in mice, rats, dogs (mg/kg): 4000, 6000, 5000 orally (deCarneri).
Melting point: mp 92-94°
Toxicity data: LD50 in mice, rats, dogs (mg/kg): 4000, 6000, 5000 orally (deCarneri)
Therap-Cat: Antifungal.
Keywords: Antifungal (Synthetic); Thiocarbamates.

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