Structural Formula Vector Image
Title: Tioconazole
CAS Registry Number: 65899-73-2
CAS Name: 1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
Additional Names: 1-[2,4-dichloro-b-[(2-chloro-3-thenyl)oxy]phenethyl]imidazole
Manufacturers' Codes: UK-20349
Trademarks: Fungibacid (Asche); Gyno-Trosyd (Pfizer); Trosyd (Pfizer); Trosyl (Pfizer); Vagistat (BMS); Zoniden (Irbi)
Molecular Formula: C16H13Cl3N2OS
Molecular Weight: 387.71
Percent Composition: C 49.57%, H 3.38%, Cl 27.43%, N 7.23%, O 4.13%, S 8.27%
Literature References: Antimycotic imidazole derivative. Prepn: G. E. Gymer, BE 841309; idem, US 4062966 (1976, 1977 both to Pfizer). Antifungal spectrum: S. Jevons, Antimicrob. Agents Chemother. 15, 597 (1979); F. C. Odds, J. Antimicrob. Chemother. 6, 749 (1980). Pharmacology: M. S. Marriott et al., Dermatologica 166, Suppl. 1, 1 (l983). Clinical trial in dermatomycosis: Y. M. Clayton et al., Clin. Exp. Dermatol. 7, 543 (1982). Series of articles on pharmacology and clinical efficacy in gynecological use: Gynak. Rundsch. 23, Suppl. 1, 1-60 (l983).
Derivative Type: Hydrochloride
Molecular Formula: C16H13Cl3N2OS.HCl
Molecular Weight: 424.17
Percent Composition: C 45.31%, H 3.33%, Cl 33.43%, N 6.60%, O 3.77%, S 7.56%
Properties: Crystals, mp 168-170°.
Melting point: mp 168-170°
Therap-Cat: Antifungal (topical).
Keywords: Antifungal (Synthetic); Imidazoles.

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