Thonzylamine Hydrochloride
Structural Formula Vector Image
Title: Thonzylamine Hydrochloride
CAS Registry Number: 63-56-9
CAS Name: N-[(4-Methoxyphenyl)methyl]-N¢,N¢-dimethyl-N-2-pyrimidinyl-1,2-ethanediamine monohydrochloride
Additional Names: 2-[(2-dimethylaminoethyl)(p-methoxybenzyl)amino]pyrimidine hydrochloride; N,N-dimethyl-N¢-(p-methoxybenzyl)-N¢-(2-pyrimidyl)ethylenediamine hydrochloride
Trademarks: Anahist (Warner-Lambert); Tonamil (Ecobi)
Molecular Formula: C16H23ClN4O
Molecular Weight: 322.83
Percent Composition: C 59.53%, H 7.18%, Cl 10.98%, N 17.35%, O 4.96%
Literature References: Histamine H1-receptor antagonist. Prepd by treating the sodium salt of 2-(p-methoxybenzyl)aminopyrimidine with N,N-dimethyl-2-chloroethylamine: Friedman, Tolstoouhov, US 2465865 (1949). Toxicity study: Reinhard, Seudi, Proc. Soc. Exp. Biol. Med. 66, 512 (1947). Spectroscopic determn in nasal drops: S. M. Sabry et al., J. Pharm. Biomed. Anal. 22, 257 (2000).
Properties: Crystals, mp 173-176° (free base, oily liq, bp2.2 185-187°). Freely sol in water; sol in alcohol, chloroform. Practically insol in ether. pH 5.1-5.7 (2% aq solution). LD50 orally in guinea pigs: 493 mg (base)/kg (Reinhard, Seudi).
Melting point: mp 173-176°
Boiling point: bp2.2 185-187°
Toxicity data: LD50 orally in guinea pigs: 493 mg (base)/kg (Reinhard, Seudi)
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic; Ethylenediamine Derivatives.

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