Structural Formula Vector Image
Title: Terodiline
CAS Registry Number: 15793-40-5
CAS Name: N-(1,1-Dimethylethyl)-a-methyl-g-phenylbenzenepropanamine
Additional Names: N-tert-butyl-1-methyl-3,3-diphenylpropylamine; N-(1-methyl-3,3-diphenylpropyl)-tert-butylamine; 4,4-diphenyl-2-(tert-butylamino)butane
Molecular Formula: C20H27N
Molecular Weight: 281.44
Percent Composition: C 85.35%, H 9.67%, N 4.98%
Literature References: Calcium antagonist with anticholinergic and vasodilatory activity. Prepn and use in treatment of angina: GB 923942; S. Carlsson, US 3371014 (1963, 1968 both to AB Recip). Pharmacokinetics: B. Karlen et al., Eur. J. Clin. Pharmacol. 23, 267 (1982). Series of articles on pharmacology and clinical efficacy in urinary frequency and motor urge incontinence: Scand. J. Urol. Nephrol. Suppl. 87, 1-61 (1984). Clinical trial in urinary incontinence: U. Ulmsten et al., Am. J. Obstet. Gynecol. 153, 619 (1985).
Properties: Yellow liquid, bp1.0 130-132°.
Boiling point: bp1.0 130-132°
Derivative Type: Hydrochloride
CAS Registry Number: 7082-21-5
Trademarks: Mictrol (Pharmacia)
Molecular Formula: C20H27N.HCl
Molecular Weight: 317.90
Percent Composition: C 75.56%, H 8.88%, N 4.41%, Cl 11.15%
Properties: Crystals from water, mp 178-180°. Sol in ethanol. Slightly sol in ether.
Melting point: mp 178-180°
Therap-Cat: Antianginal. In treatment of urinary incontinence.
Keywords: Antianginal; Calcium Channel Blocker; Arylalkylamines.
Status: This monograph has been retired and is no longer subject to revision or update.

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