Structural Formula Vector Image
Title: Terconazole
CAS Registry Number: 67915-31-5
CAS Name: rel-1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)piperazine
Additional Names: triaconazole
Manufacturers' Codes: R-42470
Trademarks: Fungistat (Cilag); Gyno-Terazol (Cilag); Terazol (Cilag); Tercospor (Cilag)
Molecular Formula: C26H31Cl2N5O3
Molecular Weight: 532.46
Percent Composition: C 58.65%, H 5.87%, Cl 13.32%, N 13.15%, O 9.01%
Literature References: Topical triazole antifungal. Prepn: J. Heeres et al., DE 2804096; eidem, US 4144346; US 4223036 (1978, 1979, 1980 all to Janssen); eidem, J. Med. Chem. 26, 611 (1983). Pharmacology: J. Van Cutsem et al., Chemotherapy 29, 322 (1983). Clinical comparison with clotrimazole in vaginal candidiasis: A. Kjaeldgaard, Pharmacotherapeutica 4, 525 (1986).
Properties: Crystals from isopropyl ether, mp 126.3°.
Melting point: mp 126.3°
Therap-Cat: Antifungal.
Keywords: Antifungal (Synthetic); Triazoles.

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