Simetride
Structural Formula Vector Image
Title: Simetride
CAS Registry Number: 154-82-5
CAS Name: 1,4-Bis[(2-methoxy-4-propylphenoxy)acetyl]piperazine
Manufacturers' Codes: AP2; Kyorin AP2
Molecular Formula: C28H38N2O6
Molecular Weight: 498.61
Percent Composition: C 67.45%, H 7.68%, N 5.62%, O 19.25%
Literature References: Prepn: FR M2936 (1964 to Kyorin Pharmaceutical Co., Ltd.); T. Irikura et al., US 3184463 (1965). Pharmacological studies: T. Irikura et al., Yakugaku Zasshi 83, 785 (1963), C.A. 60, 1008b (1964). Analgesic activity: K. Nishino et al., Yakugaku Zasshi 85, 715 (1965), C.A. 63, 16957b (1965).
Properties: Crystals, mp 128-130° (FR M2936); also reported as mp 138.5-139° (Irikura, 1963). Practically insoluble in water, ethanol. Sol in CHCl3. LD50 i.p. in mice: 15000 mg/kg (Irikura).
Melting point: mp 128-130° (FR M2936); mp 138.5-139° (Irikura, 1963)
Toxicity data: LD50 i.p. in mice: 15000 mg/kg (Irikura)
Therap-Cat: Analgesic.
Keywords: Analgesic (Non-Narcotic).

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