Structural Formula Vector Image
Title: Ramifenazone
CAS Registry Number: 3615-24-5
CAS Name: 1,2-Dihydro-1,5-dimethyl-4-[(1-methylethyl)amino]-2-phenyl-3H-pyrazol-3-one
Additional Names: 4-isopropylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one; 4-isopropylaminoantipyrine; isopropylaminophenazone; isopyrin
Molecular Formula: C14H19N3O
Molecular Weight: 245.32
Percent Composition: C 68.54%, H 7.81%, N 17.13%, O 6.52%
Literature References: Prepn: E. Skita, W. Stühmer, DE 930328; DE 932677 (both 1955), C.A. 52, 16372i, 20200h (1958). Acute toxicity: E. Tubaro et al., Arzneim.-Forsch. 20, 1024 (1970). Clinical evaluation of combination with phenylbutazone, q.v., in migraine: W. Sacks, S. Afr. Med. J. 58, 444 (1980).
Properties: Crystals from acetone + glacial acetic acid, mp 80°. LD50 in mice (mg/kg): 843 i.p.; 1070 orally (Tubaro).
Melting point: mp 80°
Toxicity data: LD50 in mice (mg/kg): 843 i.p.; 1070 orally (Tubaro)
Derivative Type: Hydrochloride monohydrate
Molecular Formula: C14H19N3O.HCl.H2O
Molecular Weight: 299.80
Percent Composition: C 56.09%, H 7.40%, N 14.02%, O 10.67%, Cl 11.83%
Derivative Type: Mixture with phenylbutazone
CAS Registry Number: 76120-72-4
Trademarks: Tomanol (Byk Gulden)
Therap-Cat: Analgesic, antipyretic, anti-inflammatory.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Pyrazolones; Antipyretic.

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