Structural Formula Vector Image
Title: Pradofloxacin
CAS Registry Number: 195532-12-8
CAS Name: 8-Cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid
Additional Names: 8-cyano-1-cyclopropyl-7-((1S,6S)-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Molecular Formula: C21H21FN4O3
Molecular Weight: 396.41
Percent Composition: C 63.63%, H 5.34%, F 4.79%, N 14.13%, O 12.11%
Literature References: Cyanofluorinated quinoline antibiotic. Prepn: S. Bartel et al., WO 9731001; eidem, US 6323213 (1997, 2001 both to Bayer). LC/MS/MS determn in biological fluids: R. Krebber, J. Vet. Pharmacol. Ther. 26, Suppl 1, 102 (2003). Bioavailability: M. A. Bregante et al., ibid. 87; K. Fraatz et al., ibid. 88. Clinical trial in dogs in comparison with amoxicillin and clavulanic acid, q.q.v.: B. Stephan et al., ibid. 217.
Properties: mp 246-248° (dec).
Melting point: mp 246-248°
Therap-Cat-Vet: Antibacterial.

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