Porfimer Sodium
Structural Formula Vector Image
Title: Porfimer Sodium
CAS Registry Number: 87806-31-3
Manufacturers' Codes: CL-184116
Trademarks: Photofrin (Axcan)
Literature References: Light sensitive polyporphyrin oligomer linked via ethers and esters; purification product of hematoporphyrin derivative. Forms aggregates with combined mol wt ~10000. Prepn: T. J. Dougherty et al., "Photoradiation Therapy - Clinical and Drug Advances" in Porphyrin Photosensitization, D. Kessel, T. J. Dougherty, Eds. (Plenum Press, New York, 1983) pp 3-13; T. J. Dougherty et al., US 4649151 (1987 to Health Res.). Structural studies: idem, Photochem. Photobiol. 46, 569 (1987); R. K. Pandey et al., Biomed. Environ. Mass Spectrom. 19, 405 (1990). Photobleaching: J. Moan, D. Kessel, J. Photochem. Photobiol. B 1, 429 (1988); J. D. Spikes, Photochem. Photobiol. 55, 797 (1992). Pharmacokinetics in mice: D. A. Bellnier et al., ibid. 50, 221 (1989). Clinical evaluation in treatment of esophageal cancer: T. Okunaka et al., Surg. Endosc. 4, 150 (1990). Imaging study for premalignant lesions: C. Liebow et al., Proc. Natl. Acad. Sci. USA 90, 1897 (1993). Clinical use as imaging agent for lung cancer: S. Lam et al., Chest 97, 333 (1990).
Properties: Orange red color.
Use: Fluorescent imaging of malignancies.
Therap-Cat: Antineoplastic (photosensitizer).
Keywords: Antineoplastic (Photosensitizer); Diagnostic Aid.

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