Ponazuril
Structural Formula Vector Image
Title: Ponazuril
CAS Registry Number: 69004-04-2
CAS Name: 1-Methyl-3-[3-methyl-4-[4-[(trifluoromethyl)sulfonyl]phenoxy]phenyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione
Additional Names: toltrazuril sulfone
Manufacturers' Codes: Bay Vi 9143
Trademarks: Marquis (Bayer)
Molecular Formula: C18H14F3N3O6S
Molecular Weight: 457.38
Percent Composition: C 47.27%, H 3.09%, F 12.46%, N 9.19%, O 20.99%, S 7.01%
Literature References: Metabolite of toltrazuril, q.v.; triazine trione antiprotozoal. Prepn: A. Haberkorn et al., DE 2718799; eidem, US 4219552 (1978, 1980 both to Bayer). Stereoselective generation by microsomes: E. Benoit et al., Biochem. Pharmacol. 46, 2337 (1993). LC/MS determn in meat and eggs: V. Hormazábal et al., J. Liq. Chromatogr. Relat. Technol. 26, 791 (2003). Activity vs Sarcocystis neurona, the causative agent of EPM: D. S. Lindsay et al., Vet. Parasitol. 92, 165 (2000); R. P. Franklin et al., ibid. 114, 123 (2003); vs Neospora canium: A. K. Darius et al., Parasitol. Res. 92, 453, 520 (2004).
Properties: mp 242°.
Melting point: mp 242°
Therap-Cat-Vet: Antiprotozoal. In treatment of equine protozoal myeloencephalitis (EPM).

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