Picosulfate Sodium
Structural Formula Vector Image
Title: Picosulfate Sodium
CAS Registry Number: 10040-45-6
CAS Name: 4,4¢-(2-Pyridinylmethylene)bisphenol bis(hydrogen sulfate) (ester) disodium salt
Additional Names: 4,4¢-(2-pyridylmethylene)diphenolbis(hydrogen sulfate) (ester) disodium salt; 4,4¢-(2-picolylidene)bis(phenylsulfuric acid) disodium salt; 2-picolylidenebis(p-phenyl sodium sulfate); disodium 4,4¢-disulfoxydiphenyl-(2-pyridyl)methane; picosulfol; sodium picosulfate
Trademarks: Guttalax-Fher (Boehringer, Ing., Italia); Laxoberal (Boehringer, Ing.); Laxoberon (Ferrosan); Neopax (Janssen); Pico-Salax (Ferring)
Molecular Formula: C18H13NNa2O8S2
Molecular Weight: 481.41
Percent Composition: C 44.91%, H 2.72%, N 2.91%, Na 9.55%, O 26.59%, S 13.32%
Literature References: Prepn: Pala, FR M5832 and US 3528986, US 3558643 (1968, 1970, 1971 all to Ist. de Angeli); Seeger, Machleidt, DE 1904322 (1970 to Thomae). Synthesis and physical-chemical data: Pala et al., Helv. Chim. Acta 51, 1164 (1968). Pharmacology: Pala et al., Arch. Int. Pharmacodyn. Ther. 164, 356 (1966). Metabolism: Perego et al., Arzneim.-Forsch. 19, 1889 (1969).
Properties: White crystalline solid from ethanol or methanol, mp 272- 275° (dec). uv max (H2O): 218, 262 nm (e 20450, 6075). Readily sol in water; slightly sol in alcohol. Practically insol in most organic solvents.
Melting point: mp 272- 275° (dec)
Absorption maximum: uv max (H2O): 218, 262 nm (e 20450, 6075)
Therap-Cat: Cathartic.
Keywords: Laxative/Cathartic.

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