Structural Formula Vector Image
Title: Pheniramine
CAS Registry Number: 86-21-5
CAS Name: N,N-Dimethyl-g-phenyl-2-pyridinepropanamine
Additional Names: 2-[a-(2-dimethylaminoethyl)benzyl]pyridine; 1-phenyl-1-(2-pyridyl)-3-dimethylaminopropane; 3-phenyl-3-(2-pyridyl)-N,N-dimethylpropylamine; prophenpyridamine; propheniramine
Molecular Formula: C16H20N2
Molecular Weight: 240.34
Percent Composition: C 79.96%, H 8.39%, N 11.66%
Literature References: Synthesis: Sperber et al., US 2567245 and US 2676964 (1951, 1954, both to Schering).
Properties: Oily liq. Slightly yellow color. Characteristic amine-like odor. d 1.0081; bp13 181°; bp2 142°; bp0.5 135°; nD25 1.5519 to 1.5521. Insol in water. Sol in dil acids, alcohol, benzene, chloroform, ether.
Boiling point: bp13 181°; bp2 142°; bp0.5 135°
Index of refraction: nD25 1.5519 to 1.5521
Density: d 1.0081
Derivative Type: Maleate
CAS Registry Number: 132-20-7
Trademarks: Avil (Aventis); Daneral (Aventis); Inhiston (Biomed. Foscama); Trimeton (Schering)
Molecular Formula: C16H20N2.C4H4O4
Molecular Weight: 356.42
Percent Composition: C 67.40%, H 6.79%, N 7.86%, O 17.96%
Properties: Crystals from amyl alcohol, faint amine-like odor, mp 107°. Freely sol in water, alcohol. Slightly sol in ether, benzene. pH of 1% aq soln between 4.3 and 4.9.
Melting point: mp 107°
Derivative Type: p-Aminosalicylate
CAS Registry Number: 3269-83-8
Molecular Formula: C16H20N2.C7H7NO3
Molecular Weight: 393.48
Percent Composition: C 70.21%, H 6.92%, N 10.68%, O 12.20%
Properties: Small needles from acetone + ethyl acetate, large octahedra from water, dec 142°. One gram dissolves in 10 ml water, freely sol in alcohol. Sparingly sol in ethyl acetate, ether, acetone.
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic; Alkylamine Derivatives.

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