Structural Formula Vector Image
Title: Phenelzine
CAS Registry Number: 51-71-8
CAS Name: (2-Phenethyl)hydrazine
Additional Names: b-phenylethylhydrazine; phenalzine
Molecular Formula: C8H12N2
Molecular Weight: 136.19
Percent Composition: C 70.55%, H 8.88%, N 20.57%
Line Formula: C6H5CH2CH2NHNH2
Literature References: Monoamine oxidase inhibitor. Prepn: Votocek, Leminger, Collect. Czech. Chem. Commun. 4, 271 (1932), C.A. 26, 5294 (1932); Biel et al., J. Am. Chem. Soc. 81, 2805 (1959); Biel, US 3000903 (1959 to Lakeside). Toxicity: J. A. Gylys et al., Ann. N.Y. Acad. Sci. 107, 899 (1963). Comprehensive description: R. E. Daly, Anal. Profiles Drug Subs. 2, 383-407 (1973).
Properties: Liquid. bp0.1 74°. nD20 1.5494.
Boiling point: bp0.1 74°
Index of refraction: nD20 1.5494
Derivative Type: Acid sulfate
CAS Registry Number: 156-51-4
Manufacturers' Codes: W-1544a
Trademarks: Nardelzine (Warner-Lambert); Nardil (Warner-Lambert)
Molecular Formula: C8H12N2.H2SO4
Molecular Weight: 234.27
Percent Composition: C 41.01%, H 6.02%, N 11.96%, S 13.69%, O 27.32%
Properties: White powder, sol in water. LD50 orally in mice: 156 mg/kg (Gylys).
Toxicity data: LD50 orally in mice: 156 mg/kg (Gylys)
Derivative Type: Hydrochloride
Molecular Formula: C8H12N2.HCl
Molecular Weight: 172.66
Percent Composition: C 55.65%, H 7.59%, N 16.22%, Cl 20.53%
Properties: Crystals, mp 174°.
Melting point: mp 174°
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Hydrazides/Hydrazines; Monoamine Oxidase Inhibitor.

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