Structural Formula Vector Image
Title: Pemetrexed
CAS Registry Number: 137281-23-3
CAS Name: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid
Molecular Formula: C20H21N5O6
Molecular Weight: 427.41
Percent Composition: C 56.20%, H 4.95%, N 16.39%, O 22.46%
Literature References: Multitargeted antifolate; inhibits thymidylate synthase as well as other folate dependent enzymes. Prepn: E. C. Taylor et al., EP 432677; idem, US 5344932 (1991, 1994 both to Trustees Princeton Univ.); idem et al., J. Med. Chem. 35, 4450 (1992). Profile of enzyme inhibition: C. Shih et al., Adv. Enzyme Regul. 38, 135 (1998). HPLC determn in plasma: C. L. Hamilton, J. A. Kirkwood, J. Chromatogr. B 654, 297 (1994). Clinical pharmacokinetics in cancer patients: A. C. McDonald et al., Clin. Cancer Res. 4, 605 (1998). Clinical evaluation in colorectal carcinoma: W. John et al., Cancer 88, 1807 (2000); in pancreatic cancer: K. D. Miller et al., Ann. Oncol. 11, 101 (2000).
Properties: Crystals from 50% methanol/methylene chloride.
Derivative Type: Sodium salt
CAS Registry Number: 150399-23-8
Additional Names: Pemetrexed disodium
Manufacturers' Codes: LY-231514
Trademarks: Alimta (Lilly)
Molecular Formula: C20H19N5Na2O6
Molecular Weight: 471.37
Percent Composition: C 50.96%, H 4.06%, N 14.86%, Na 9.75%, O 20.37%
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antimetabolites; Folic Acid Analogs/Antagonists.

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