Ninopterin
Structural Formula Vector Image
Title: Ninopterin
CAS Registry Number: 2179-16-0
CAS Name: N-[4-[[1-(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]-L-glutamic acid
Additional Names: 9-methylpteroylglutamic acid; 9-methylfolic acid
Trademarks: Bremfol
Molecular Formula: C20H21N7O6
Molecular Weight: 455.42
Percent Composition: C 52.75%, H 4.65%, N 21.53%, O 21.08%
Literature References: Folic acid analog. Prepn: Hultquist et al., J. Am. Chem. Soc. 71, 619 (1949); Hultquist, Smith, GB 667098 (1952 to Am. Cyanamid). Clinical study in neoplastic diseases: J. C. Wright et al., J. Natl. Med. Assoc. 43, 211 (1951). In vitro evaluation as folic acid antagonist: S. Waxman et al., Chemotherapy (Basel) 28, 402 (1982).
Properties: uv max in 0.1N NaOH: 255, 283, 365 nm (e 26, 30, 8 ´ 103); in 0.1N HCl: 297 nm (e 18 ´ 103).
Absorption maximum: uv max in 0.1N NaOH: 255, 283, 365 nm (e 26, 30, 8 ´ 103); in 0.1N HCl: 297 nm (e 18 ´ 103)
Therap-Cat: Experimental antineoplastic.

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