Structural Formula Vector Image
Title: Midodrine
CAS Registry Number: 42794-76-3
CAS Name: 2-Amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide
Additional Names: 1-(2¢,5¢-dimethoxyphenyl)-2-glycinamidoethanol
Molecular Formula: C12H18N2O4
Molecular Weight: 254.28
Percent Composition: C 56.68%, H 7.14%, N 11.02%, O 25.17%
Literature References: a-Adrenergic agonist. Prepn: K. Wismayr et al., AT 241435; eidem, US 3340298 (1965, 1967 both to OSSW). Hemodynamic effects: G. Hitzenberger et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 7, 323 (1973). Pharmacodynamic actions: H. Pittner et al., Arzneim.-Forsch. 26, 2145 (1976). Plasma levels: N. Kolassa et al., Arch. Int. Pharmacodyn. Ther. 238, 96 (1979). Use in ejaculation disorders: D. Jonas et al., Eur. Urol. 5, 184 (1979); in circulatory disorders: H. Sazovsky, H. Pittner, Fortschr. Med. 97, 733 (1979). Synthesis of potential metabolites: T. Kappe, W. Witoszynaky, Arch. Pharm. 308, 339 (1975).
Derivative Type: Hydrochloride
CAS Registry Number: 3092-17-9
Manufacturers' Codes: ST-1085
Trademarks: Amatine (Roberts); Gutron (Nycomed); Hipertan (Gramon); Metligine (Taisho); ProAmatine (Roberts)
Molecular Formula: C12H18N2O4.HCl
Molecular Weight: 290.74
Percent Composition: C 49.57%, H 6.59%, N 9.64%, O 22.01%, Cl 12.19%
Properties: Crystals, mp 192-193°.
Melting point: mp 192-193°
Therap-Cat: Antihypotensive.
Keywords: a-Adrenergic Agonist; Antihypotensive.

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