Methyl Aminolevulinate
Structural Formula Vector Image
Title: Methyl Aminolevulinate
CAS Registry Number: 33320-16-0
CAS Name: 5-Amino-4-oxopentanoic acid methyl ester
Manufacturers' Codes: P-1202
Molecular Formula: C6H11NO3
Molecular Weight: 145.16
Percent Composition: C 49.64%, H 7.64%, N 9.65%, O 33.07%
Literature References: Prodrug of d-aminolevulinic acid, q.v.; induces production of intracellular protoporphyrin IX. Prepn: S. I. Zav'yalov, A. G. Zavozin, Bull. Acad. Sci. USSR Div. Chem. Sci. 36, 1663 (1987). Porphyrin enrichment in solar keratoses: C. Fritsch et al., Photochem. Photobiol. 68, 218 (1998). Clinical trial in photodynamic therapy of basal cell carcinomas: A. M. Soler et al., Br. J. Dermatol. 145, 467 (2001); C. Vinciullo et al., Br. J. Dermatol. 152, 765 (2005); in actinic keratosis: R. M. Szeimies et al., J. Am. Acad. Dermatol. 47, 258 (2002). Review of pharmacology and clinical experience: M. A. A. Siddiqui et al., Am. J. Clin. Dermatol. 5, 127-137 (2004).
Derivative Type: Hydrochloride
CAS Registry Number: 79416-27-6
Trademarks: Metvix (PhotoCure)
Molecular Formula: C6H11NO3.HCl
Molecular Weight: 181.62
Percent Composition: C 39.68%, H 6.66%, N 7.71%, O 26.43%, Cl 19.52%
Properties: mp 119-121°.
Melting point: mp 119-121°
Therap-Cat: Antineoplastic (photosensitizer).
Keywords: Antineoplastic (Photosensitizer).

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