Lynestrenol
Structural Formula Vector Image
Title: Lynestrenol
CAS Registry Number: 52-76-6
CAS Name: (17a)-19-Norpregn-4-en-20-yn-17-ol
Additional Names: 17a-ethinyl-17b-hydroxyestr-4-ene; 17a-ethynylestr-4-en-17b-ol; 3-desoxynorlutin; ethinylestrenol
Trademarks: Exluton(a) (Organon); Exlutena (Organon); Orgametril (Organon); Orgametil
Molecular Formula: C20H28O
Molecular Weight: 284.44
Percent Composition: C 84.45%, H 9.92%, O 5.62%
Literature References: Prepn: de Winter et al., Chem. Ind. (London) 1959, 905. Metabolism: Kamyab et al., Biochem. J. 103, 14P (1967); J. Endocrinol. 42, 337 (1968). Pharmacokinetics and metabolism: H. Kuhl et al., Contraception 26, 303 (1982). Clinical trial of use in normophasic oral contraceptives: N. Dombrowicz et al., ibid. 22, 537 (1980). Review of carcinogenicity studies: IARC Monographs 21, 407-415 (1979).
Properties: Solid, mp 158-160°. [a]D -13° (chloroform).
Melting point: mp 158-160°
Optical Rotation: [a]D -13° (chloroform)
 
Derivative Type: Mixture with ethinyl estradiol
CAS Registry Number: 8064-76-4
Trademarks: Fysionorm (Nourypharma); Minilyn (Organon); Ovanon (Nourypharma); Ovoresta (Organon); Yermonil (Novartis)
 
Derivative Type: Mixture with mestranol
CAS Registry Number: 8015-14-3
Trademarks: Lyndiol (Organon)
 
Therap-Cat: Progestogen. In combination with estrogen as oral contraceptive.
Keywords: Contraceptive (Oral); Progestogen.

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