Structural Formula Vector Image
Title: Limaprost
CAS Registry Number: 74397-12-9
CAS Name: (2E,11a,13E,15S,17S)-11,15-Dihydroxy-17,20-dimethyl-9-oxoprosta-2,13-dien-1-oic acid
Additional Names: 17S,20-dimethyl-trans-2,3-didehydro-PGE1; 9-oxo-11a,15a-dihydroxy-17S,20-dimethylprosta-trans-2,trans-13-dienoic acid; 17S-methyl-w-homo-trans-D2-PGE1
Manufacturers' Codes: ONO-1206; OP-1206
Trademarks: Opalmon (Ono); Prorenal (Dainippon)
Molecular Formula: C22H36O5
Molecular Weight: 380.52
Percent Composition: C 69.44%, H 9.54%, O 21.02%
Literature References: Derivative of prostaglandin E1, q.v. Prepn: M. Hayashi et al., DE 3002677 (1980 to Ono); eidem, US 4294849 (1981 to Warner-Lambert). Cardiovascular pharmacology in animals: T. Tsuboi et al., Arch. Int. Pharmacodyn. 247, 89 (1980). Effect on smooth muscle in vitro: P. G. Adaikan, S. M. M. Karim, Prostaglandins Med. 6, 449 (1981). Coronary vasodilating effects in primates: S. R. Kottegoda et al., Prostaglandins Leukotrienes Med. 8, 343 (1982). Clinical hemodynamics in chronic lung disease: T. Ishizaki et al., Chest 85, 382 (1984).
Properties: White crystals, mp 97-100°.
Melting point: mp 97-100°
Therap-Cat: Antianginal.
Keywords: Antianginal; Prostaglandin/Prostaglandin Analog.

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