Structural Formula Vector Image
Title: Isofezolac
CAS Registry Number: 50270-33-2
CAS Name: 1,3,4-Triphenyl-1H-pyrazole-5-acetic acid
Manufacturers' Codes: LM-22102
Trademarks: Sofenac (Rh>e-Poulenc)
Molecular Formula: C23H18N2O2
Molecular Weight: 354.40
Percent Composition: C 77.95%, H 5.12%, N 7.90%, O 9.03%
Literature References: Non-steroidal anti-inflammatory agent; prostaglandin synthetase inhibitor. Prepn: C. Gueremy, C. Renault, DE 2312256; eidem, US 3984431 (1973, 1976 to Société Générale de Recherches et d'Applications Scientifiques). Pharmacology: J. Mizoule et al., Arch. Int. Pharmacodyn. 238, 305 (1979). HPLC determn in biological fluids: A. Bannier et al., J. Chromatogr. 227, 213 (1982).
Properties: Crystals from acetonitrile, mp 200°. LD50 in mice, rats (mg/kg): 215, 13 orally (Mizoule).
Melting point: mp 200°
Toxicity data: LD50 in mice, rats (mg/kg): 215, 13 orally (Mizoule)
Therap-Cat: Anti-inflammatory; antipyretic; analgesic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives; Antipyretic.
Status: This monograph has been retired and is no longer subject to revision or update.

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