Structural Formula Vector Image
Title: Holarrhenine
CAS Registry Number: 561-22-8
CAS Name: (3b,12b)-3-(Dimethylamino)con-5-enin-12-ol
Additional Names: 12b-hydroxyconessine
Molecular Formula: C24H40N2O
Molecular Weight: 372.59
Percent Composition: C 77.37%, H 10.82%, N 7.52%, O 4.29%
Literature References: From leaves and bark of Holarrhena congolensis Stapf, Apocynaceae. Isoln: Pyman, J. Chem. Soc. 115, 163 (1919). Structure: Uffer, Helv. Chim. Acta 39, 1834 (1956); van Hove, Tetrahedron 7, 104 (1959).
Properties: Needles from acetic acid or ethyl acetate, mp 197-198°. [a]D24 -7° (chloroform); [a]D24 +9° (alcohol). Practically insol in water. Sol in alcohol, chloroform, slightly in ether, acetone, ethyl acetate.
Melting point: mp 197-198°
Optical Rotation: [a]D24 -7° (chloroform); [a]D24 +9° (alcohol)
Derivative Type: O-Acetylholarrhenine
Molecular Formula: C26H42N2O2
Molecular Weight: 414.62
Percent Composition: C 75.32%, H 10.21%, N 6.76%, O 7.72%
Properties: Crystals from pentane or acetone, mp 177-178°.
Melting point: mp 177-178°
Status: This monograph has been retired and is no longer subject to revision or update.

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