Structural Formula Vector Image
Title: Hexamidine
CAS Registry Number: 3811-75-4
CAS Name: 4,4¢-[1,6-Hexanediylbis(oxy)]bisbenzenecarboximidamide
Additional Names: 4,4¢-(hexamethylenedioxy)dibenzamidine; 4,4¢-diamidino-a,w-diphenoxyhexane
Molecular Formula: C20H26N4O2
Molecular Weight: 354.45
Percent Composition: C 67.77%, H 7.39%, N 15.81%, O 9.03%
Literature References: Prepn: A. J. Ewins et al., GB 507565 (1939 to May & Baker); and trypanocidal activity: J. N. Ashley et al., J. Chem. Soc. 1942, 103. Activity in fibrinolytic systems: J. D. Geratz, Thromb. Diath. Haemorrh. 29, 154 (1973). Antibacterial activity: G. Michel et al., J. Int. Med. Res. 14, 205 (1986). Antifungal activity: M. C. Reynaud, C. Chauve, Bull. Soc. Fr. Mycol. Med. 15, 269 (1986). HPLC determn in pharmaceutics: P. Taylor et al., J. Pharm. Sci. 72, 1477 (1983); in cosmetics: B. Wyhowski de Bukanski, M. O. Masse, Int. J. Cosmet. Sci. 6, 283 (1984). Clinical use as a topical antiseptic: M. J. Fénelon, Bordeaux Med. 3, 867 (1970). Use in treatment of acne: P. Taylor, A. A. Levy, EP 93186 (1983 to Richardson-Vicks). Amebicidal effects: D. Perrine et al., Antimicrob. Agents Chemother. 39, 339 (1995).
Derivative Type: Isethionate
CAS Registry Number: 659-40-5
Manufacturers' Codes: RF-2535
Trademarks: Desomedine (Chauvin); Hexomedin (Sanofi-Aventis)
Molecular Formula: C24H38N4O10S2
Molecular Weight: 606.71
Percent Composition: C 47.51%, H 6.31%, N 9.23%, O 26.37%, S 10.57%
Properties: Prisms from HCl, mp 246-247° (dec).
Melting point: mp 246-247° (dec)
Use: Preservative in cosmetics.
Therap-Cat: Antiseptic (topical).
Keywords: Antiseptic/Disinfectant.

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