Fluprednidene Acetate
Structural Formula Vector Image
Title: Fluprednidene Acetate
CAS Registry Number: 1255-35-2
CAS Name: (11b)-21-(Acetyloxy)-9-fluoro-11,17-dihydroxy-16-methylenepregna-1,4-diene-3,20-dione
Additional Names: 9a-fluoro-11b,17,21-trihydroxy-16-methylenepregna-1,4-diene-3,20-dione 21-acetate; 9a-fluoro-16-methylene-D1,4-pregnadiene-11b,17,21-triol-3,20-dione 21-acetate; 16-methylene-9a-fluoroprednisolone 21-acetate; 9a-fluoro-16-methyleneprednisolone 21-acetate; fluprednylidene 21-acetate
Manufacturers' Codes: StL-1106
Trademarks: Etacortin (Hermal); Decoderm (Merck KGaA)
Molecular Formula: C24H29FO6
Molecular Weight: 432.48
Percent Composition: C 66.65%, H 6.76%, F 4.39%, O 22.20%
Literature References: Prepn: Taub et al., J. Org. Chem. 25, 2258 (1960); 29, 3486 (1964); v. Werder et al., Arzneim.-Forsch. 18, 7 (1968); Wendler, Taub; Taub, Wendler; Taub et al.; Wendler et al., US 3065239; US 3068224; US 3068226 and US 3136760 (1960 and 1964 to Merck & Co.).
Properties: Crystals, mp 231-234°. [a]D +43° (CHCl3); [a]D +32° (dioxane) (v. Werder). uv max (methanol): 238 nm (e 15700).
Melting point: mp 231-234°
Optical Rotation: [a]D +43° (CHCl3); [a]D +32° (dioxane) (v. Werder)
Absorption maximum: uv max (methanol): 238 nm (e 15700)
Therap-Cat: Anti-inflammatory (topical).
Keywords: Glucocorticoid.

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