Structural Formula Vector Image
Title: Fenproporex
CAS Registry Number: 15686-61-0
CAS Name: 3-[(1-Methyl-2-phenylethyl)amino]propanenitrile
Additional Names: (±)-3-[(a-methylphenethyl)amino]propionitrile; (±)-N-2-cyanoethylamphetamine
Molecular Formula: C12H16N2
Molecular Weight: 188.27
Percent Composition: C 76.55%, H 8.57%, N 14.88%
Literature References: Deriv of amphetamine, q.v. Prepn: FR M4364; P. Pohrbach, J. Blum, US 3485924 (1966, 1969 both to Bottu). Pharmacological studies: B. M. Beecham et al., J. Pharm. Pharmacol. 23, 140 (1971); A. H. Beckett et al., ibid. 24, 194 (1972). Peripheral effects in human and rat adipose tissue: M. Dubost et al., Br. J. Pharmacol. 58, 436P (1976). Chromatographic identification of amphetamine in urine of patients treated with fenproporex: R. B. Sznelvar, Eur. J. Toxicol. Environ. Hyg. 8, 5 (1975). Clinical trial: G. Hertel, W. Fallot-Burghardt, Fortschr. Med. 96, 2380 (1978).
Properties: Liquid, bp2 126-127°.
Boiling point: bp2 126-127°
Derivative Type: Hydrochloride
CAS Registry Number: 18305-29-8
Trademarks: Gacilin (Andromaco); Solvolip (Knoll)
Molecular Formula: C12H16N2.HCl
Molecular Weight: 224.73
Percent Composition: C 64.13%, H 7.62%, N 12.47%, Cl 15.78%
Properties: White, cryst, odorless powder from abs ethanol, mp 146°. Bitter taste. Sol in water, 95% ethanol.
Melting point: mp 146°
NOTE: This is a controlled substance (stimulant): 21 CFR, 1308.14.
Therap-Cat: Anorexic.
Keywords: Anorexic.

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