Ethyl Loflazepate
Structural Formula Vector Image
Title: Ethyl Loflazepate
CAS Registry Number: 29177-84-2
CAS Name: 7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-2-oxo-1H-1,4-benzodiazepine-3-carboxylic acid ethyl ester
Additional Names: ethyl 7-chloro-5-(o-fluorophenyl)-2,3-dihydro-2-oxo-1H-1,4-benzodiazepine-3-carboxylate
Manufacturers' Codes: CM-6912
Trademarks: Meilax (Meiji Seika); Victan (Sanofi Winthrop)
Molecular Formula: C18H14ClFN2O3
Molecular Weight: 360.77
Percent Composition: C 59.93%, H 3.91%, Cl 9.83%, F 5.27%, N 7.76%, O 13.30%
Literature References: Benzodiazepine tranquilizer. Prepn: J. Hellerbach et al., DE 2001276; eidem, US 3657223 (1970, 1972 both to Hoffmann-La Roche). Analysis in plasma and urine: W. Cantreels, J. R. Jeanniot, Biomed. Mass Spectrom. 7, 565 (1980). GC analysis of metabolites: J. P. Cano, J. Chromatogr. 226, 413 (1981). Toxicologic evaluation: G. Mozue et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 19, 453 (1981).
Properties: Crystals from ether, mp 193-194°.
Melting point: mp 193-194°
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic; Benzodiazepine Derivatives.

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