Structural Formula Vector Image
Title: Doramectin
CAS Registry Number: 117704-25-3
CAS Name: 25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a
Additional Names: 25-cyclohexylavermectin B1
Manufacturers' Codes: UK-67994
Trademarks: Dectomax (Pfizer)
Molecular Formula: C50H74O14
Molecular Weight: 899.11
Percent Composition: C 66.79%, H 8.30%, O 24.91%
Literature References: Mutational biosynthetic antiparasitic antibiotic structurally related to the avermectins, q.v. Isoln: S. P. Gibson et al., EP 214731; eidem, US 5089480 (1987, 1992 both to Pfizer). Mutational biosynthesis: C. J. Dutton et al., J. Antibiot. 44, 357 (1991). Pharmacokinetics and efficacy in cattle: Vet. Parasitol. 49, 1-119 (1993). Clinical evaluation as prophylactic in canine spirocercosis: E. Lavy et al., Res. Vet. Sci. 75, 217 (2003).
Properties: mp 116-119°.
Melting point: mp 116-119°
Therap-Cat-Vet: Antiparasitic.

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