Structural Formula Vector Image
Title: Ditazol
CAS Registry Number: 18471-20-0
CAS Name: 2,2¢-[(4,5-Diphenyl-2-oxazolyl)imino]bisethanol
Additional Names: N-(4,5-diphenyloxazol-2-yl)diethanolamine; 2-[bis(b-hydroxyethyl)amino]-4,5-diphenyloxazole; 2,2¢-dihydroxy-N-(4,5-diphenyloxazol-2-yl)diethylamine; diethamphenazol
Manufacturers' Codes: S-222
Trademarks: Ageroplas (Serono)
Molecular Formula: C19H20N2O3
Molecular Weight: 324.37
Percent Composition: C 70.35%, H 6.21%, N 8.64%, O 14.80%
Literature References: Prepn: Marchetti et al., J. Med. Chem. 11, 1092 (1968); FR 1538009; E. Marchetti, US 3557135 (1968, 1971 to Ist. Farmacol. Serono). Series of articles on pharmacology and toxicology: L. Caprino et al., Arzneim.-Forsch. 23, 1272-1291 (1973). Metabolism: Marchetti et al., ibid. 1291.
Derivative Type: Monohydrate
Properties: Crystals from ethyl ether-petr ether, mp 96-98°. LD50 in mice, rats (mg/kg): 9621, 11380 orally; 3390, 7770 i.p. (Caprino).
Melting point: mp 96-98°
Toxicity data: LD50 in mice, rats (mg/kg): 9621, 11380 orally; 3390, 7770 i.p. (Caprino)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal).

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