Chlorphenesin Carbamate
Structural Formula Vector Image
Title: Chlorphenesin Carbamate
CAS Registry Number: 886-74-8
CAS Name: 3-(4-Chlorophenoxy)-1,2-propanediol-1-carbamate
Additional Names: carbamic acid 3-(p-chlorophenoxy)-2-hydroxypropyl ester; 3-(p-chlorophenoxy)-2-hydroxypropyl carbamate; 1,2-propanediol-3-(p-chlorophenoxy)-1-carbamate
Trademarks: Maolate (Upjohn); Rinlaxer (Taisho)
Molecular Formula: C10H12ClNO4
Molecular Weight: 245.66
Percent Composition: C 48.89%, H 4.92%, Cl 14.43%, N 5.70%, O 26.05%
Literature References: Prepn: Collins, Matthews, US 3161567; Parker, US 3214336 (1964, 1965 both to Upjohn). Clinical evaluation of analgesic activity: L. J. Cass, W. S. Frederick, J. New Drugs 2, 366 (1962).
Properties: Crystals from benzene + toluene, mp 89-91°. Readily sol in 95% ethanol, acetone, ethyl acetate; fairly readily sol in dioxane. Almost insol in cold water, benzene, cyclohexane. LD50 orally in rats: 748 mg/kg; i.v. in mice: 239 mg/kg (Cass, Frederick).
Melting point: mp 89-91°
Toxicity data: LD50 orally in rats: 748 mg/kg; i.v. in mice: 239 mg/kg (Cass, Frederick)
Therap-Cat: Muscle relaxant (skeletal).
Therap-Cat-Vet: Muscle relaxant (skeletal).
Keywords: Muscle Relaxant (Skeletal).

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