Carbocysteine
Structural Formula Vector Image
Title: Carbocysteine
CAS Registry Number: 638-23-3
CAS Name: S-(Carboxymethyl)-L-cysteine
Additional Names: 3-[(carboxymethyl)thio]alanine; S-carboxymethylcysteine
Manufacturers' Codes: AHR-3053; LJ-206
Trademarks: Carbocit (CT); Fluifort (Domp?; Lisomucil (Sanofi-Synthelabo); Loviscol (Wyeth); Muciclar (Pfizer); Mucocis (So.Se.); Mucodyne (Sanofi-Aventis); Mucolase (Lampugnani); Mucolex (Warner-Lambert); Mucopront (Mack, Illert.); Pectox (Italfarmaco); Pulmoclase (UCB); Reomucil (DOC); Rhinathiol (Sanofi-Synthelabo); Siroxyl (Aventis); Transbronchin (Viatris)
Molecular Formula: C5H9NO4S
Molecular Weight: 179.19
Percent Composition: C 33.51%, H 5.06%, N 7.82%, O 35.71%, S 17.89%
Line Formula: HOOCCH2SCH2CH(NH2)COOH
Literature References: Prepn: Armstrong, Lewis, J. Org. Chem. 16, 749 (1951); Schöberl, Wagner, Z. Physiol. Chem. 304, 97 (1956); Foye, Verderame, J. Am. Pharm. Assoc. 46, 273 (1957); Goodman et al., J. Org. Chem. 23, 1251 (1958). Pharmacology: Huyen-Vu-Ngoc et al., C.R. Seances Soc. Biol. Ses Fil. 160, 1849 (1966); Quevauviller et al., Therapie 22, 485 (1967). Clinical trial in chronic bronchitis: M. Grillage, K. Bernard-Jones, Br. J. Clin. Pract. 39, 395 (1985). Review of pharmacology and clinical uses: D. T. Brown, Drug Intell. Clin. Pharm. 22, 603-608 (1988).
 
Derivative Type: L-Form
Properties: mp 204-207°. [a]D24 +0.5° (1N HCl).
Melting point: mp 204-207°
Optical Rotation: [a]D24 +0.5° (1N HCl)
 
Derivative Type: DL-Form
Properties: Spherical aggregates of needles.
 
Therap-Cat: Mucolytic; expectorant.
Keywords: Expectorant; Mucolytic.

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