Bifemelane
Structural Formula Vector Image
Title: Bifemelane
CAS Registry Number: 90293-01-9
CAS Name: N-Methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine
Additional Names: 4-(o-benzylphenoxy)-N-methylbutylamine; 2-(4-methylaminobutoxy)diphenylmethane; 2-benzyl-1-[4-(methylamino)butoxy]benzene
Molecular Formula: C18H23NO
Molecular Weight: 269.38
Percent Composition: C 80.26%, H 8.61%, N 5.20%, O 5.94%
Literature References: Monoamine oxidase inhibitor. Prepn: R. Kikumoto et al., DE 2627227; eidem, US 4091114 (1976, 1978 both to Mitsubishi); and antidepressant activity: R. Kikumoto et al., J. Med. Chem. 24, 145 (1981). Pharmacology: A. Tobe et al., Arzneim.-Forsch. 31, 1278 (1981). Effects on experimental amnesia in rats: A. Tobe et al., Jpn. J. Pharmacol. 39, 153 (1985). Effects on neuronal activity in cats: M. Egawa et al., Neuropharmacology 26, 379 (1987). Inhibition of MAO: M. Naoi et al., J. Neurochem. 50, 243 (1988).
 
Derivative Type: Hydrochloride
CAS Registry Number: 62232-46-6
Manufacturers' Codes: E-0687; MCI-2016
Trademarks: Alnert (Fujisawa); Celeport (Eisai)
Molecular Formula: C18H23NO.HCl
Molecular Weight: 305.84
Percent Composition: C 70.69%, H 7.91%, N 4.58%, O 5.23%, Cl 11.59%
Properties: Crystals from acetone, mp 117-121°. LD50 in mice, rats (mg/kg): 1000, 1080 orally; 173, 130 i.p. (Tobe, 1981).
Melting point: mp 117-121°
Toxicity data: LD50 in mice, rats (mg/kg): 1000, 1080 orally; 173, 130 i.p. (Tobe, 1981)
 
Therap-Cat: Nootropic.
Keywords: Nootropic.

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