Amphenone B
Structural Formula Vector Image
Title: Amphenone B
CAS Registry Number: 2686-47-7
CAS Name: 3,3-Bis[4-aminophenyl]-2-butanone
Additional Names: amphenone; 2-oxo-3,3-bis[p-aminophenyl]butane
Molecular Formula: C16H18N2O
Molecular Weight: 254.33
Percent Composition: C 75.56%, H 7.13%, N 11.01%, O 6.29%
Literature References: Prepn: Allen, Corwin, J. Am. Chem. Soc. 72, 117 (1950); US 2539388 (1951). Structure: Bencze, Allen, J. Org. Chem. 22, 352 (1957). Shows antiestrogenic activity in the chick oviduct test: Hertz et al., Recent Prog. Horm. Res. 11, 119-147 (1955). Decreases adrenal action. Review: Subsidia Med. 10, 99-102 (1958).
Properties: Crystals, mp 137.5-138°.
Melting point: mp 137.5-138°
Derivative Type: Dihydrochloride
Molecular Formula: C16H20Cl2N2O
Molecular Weight: 327.25
Percent Composition: C 58.72%, H 6.16%, Cl 21.67%, N 8.56%, O 4.89%
Properties: Crystals from ethanol, dec 272-275°. Soluble in water.
NOTE: Formerly a pinacolone structure was assigned to amphenone B: 1,2-Bis[p-aminophenyl]-2-methyl-1-propanone.
Use: In biological research.

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