Structural Formula Vector Image
Title: Amobarbital
CAS Registry Number: 57-43-2
CAS Name: 5-Ethyl-5-(3-methylbutyl)-2,4,6-(1H,3H,5H)-pyrimidinetrione
Additional Names: 5-ethyl-5-isopentylbarbituric acid; 5-ethyl-5-isoamylbarbituric acid; barbamil; amylobarbitone; 5-isoamyl-5-ethylbarbituric acid; pentymal
Trademarks: Amal (Knoll); Amasust (Knoll); Amytal (Flynn); Eunoctal (Houd?; Isomytal (Nippon Shinyaku); Mylodorm (G.P.); Sednotic (Dista); Stadadorm (Stada)
Molecular Formula: C11H18N2O3
Molecular Weight: 226.27
Percent Composition: C 58.39%, H 8.02%, N 12.38%, O 21.21%
Literature References: Prepn: US 1514573 (1924). Metabolism: Frey, Magnussen, Arzneim.-Forsch. 16, 612 (1966). Toxicity data: K. Irrgang, ibid. 15, 688 (1965). Comprehensive description: N. A. A. Mian et al., Anal. Profiles Drug Subs. 19, 27-58 (1990).
Properties: Slightly bitter crystals, mp 156-158°. One gram dissolves in 1300 ml water, in 5 ml alc, in 17 ml chloroform, in 6 ml ether. Freely sol in benzene; sol in alkaline solns. Insol in petr ether, aliphatic hydrocarbons. A satd aq soln is acid to litmus paper. Dissolves in aq solns of alkali hydroxides and carbonates. pH of a saturated soln in water about 5.6. pKa (25°C) 8.0. LD50 in mice (mg/kg): 212 s.c. (Irrgang).
Melting point: mp 156-158°
pKa: pKa (25°C) 8.0
Toxicity data: LD50 in mice (mg/kg): 212 s.c. (Irrgang)
Derivative Type: Sodium salt
CAS Registry Number: 64-43-7
Trademarks: Sodium Amytal (Flynn)
Molecular Formula: C11H17N2NaO3
Molecular Weight: 248.25
Percent Composition: C 53.22%, H 6.90%, N 11.28%, Na 9.26%, O 19.33%
Properties: Hygroscopic, friable granules of powder. Slightly bitter taste. Very soluble in water; sol in alcohol (1:1). Practically insol in ether.
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.12 and 1308.13.
Therap-Cat: Sedative, hypnotic.
Therap-Cat-Vet: Sedative, hypnotic.
Keywords: Sedative/Hypnotic; Barbituric Acid Derivatives.

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