Structural Formula Vector Image
Title: Amiphenazole
CAS Registry Number: 490-55-1
CAS Name: 5-Phenyl-2,4-thiazolediamine
Additional Names: 2,4-diamino-5-phenylthiazole; DAPT; phenamizole
Trademarks: Dizol; Daptazole (Nicholas); Daptazile; Fenamizol
Molecular Formula: C9H9N3S
Molecular Weight: 191.25
Percent Composition: C 56.52%, H 4.74%, N 21.97%, S 16.77%
Literature References: Prepd by the interaction of thiourea and a-bromobenzyl cyanide in alcohol: Davies et al., J. Chem. Soc. 1950, 3491; from thiourea and a-cyanobenzyl benzenesulfonate in acetone: Dodson, Turner, J. Am. Chem. Soc. 73, 4517 (1951).
Properties: Flakes from water or dilute alcohol, dec 163-164°. Turns brown on exposure to light and air.
Derivative Type: Hydrobromide
Molecular Formula: C9H9N3S.HBr
Molecular Weight: 272.16
Percent Composition: C 39.72%, H 3.70%, N 15.44%, S 11.78%, Br 29.36%
Properties: Prisms from alc, dec >250°. Freely sol in hot water, moderately in cold water.
Derivative Type: Benzenesulfonate
Molecular Formula: C15H15N3O3S2
Molecular Weight: 349.43
Percent Composition: C 51.56%, H 4.33%, N 12.03%, O 13.74%, S 18.35%
Properties: Crystals from alcohol + ether, dec 261-262°. Practically insol in water, most organic solvents. Slightly sol in alcohol.
Therap-Cat: Narcotic antagonist.
Therap-Cat-Vet: Barbiturate and morphine antagonist.
Keywords: Narcotic Antagonist.

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