2'-Cytidylic Acid
Structural Formula Vector Image
Title: 2¢-Cytidylic Acid
CAS Registry Number: 85-94-9
Additional Names: Cytidine-2¢-monophosphate; cytidylic acid a; 2¢-cytidinephosphoric acid; cytidine-2¢-phosphate; 2¢-cytosylic acid; 2¢-CMP
Molecular Formula: C9H14N3O8P
Molecular Weight: 323.20
Percent Composition: C 33.45%, H 4.37%, N 13.00%, O 39.60%, P 9.58%
Literature References: Ribonuclease inhibitor. Prepn from yeast ribonucleic acid: Cohn, Carter, J. Am. Chem. Soc. 72, 2606 (1950); Loring et al., J. Biol. Chem. 196, 807 (1952); by phosphorylation of N6,O3¢,O5¢-tribenzoylcytidine: Rammler, Khorana, J. Am. Chem. Soc. 84, 3112 (1962). Crystal structure and conformation of the trihydrate: Kartha et al., Science 179, 495 (1973). Reviews: See Cytidine.
Properties: Crystals, dec 238-240°. [a]D20 +20.7° (water); [a]D25 -3° (aq NaOH adjusted to pH 10). uv max at pH 2: 278 nm (e 12.7); at pH 12: 272 nm (e 8.6). pKa1 0.8; pKa2 4.36; pKa3 6.17. Sparingly sol in water. Less sol than 3¢-cytidylic acid.
pKa: pKa1 0.8; pKa2 4.36; pKa3 6.17
Optical Rotation: [a]D20 +20.7° (water); [a]D25 -3° (aq NaOH adjusted to pH 10)
Absorption maximum: uv max at pH 2: 278 nm (e 12.7); at pH 12: 272 nm (e 8.6)

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