Tromethamine (troe meth' a meen). 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-. 2-Amino-2-(hydroxymethyl)-1,3-propanediol[77-86-1]. » Tromethamine contains not less than 99.0 percent and not more than 101.0 percent of C4H11NO3, calculated on the dried basis. Packaging and storagePreserve in tight containers. Identification B: To 4.5 mL of a saturated solution of salicylaldehyde add 0.5 mL of glacial acetic acid, and mix. Add 4.0 mL of a solution of Tromethamine (1 in 5), and mix: a yellow color is produced. C: To 0.5 mL of a 4 in 10 solution of ceric ammonium nitrate in 2 N nitric acid add 3 mL of water and 0.5 mL of a solution of Tromethamine (1 in 5), and mix: the color changes from light yellow to orange. Melting range 741: between 168 and 172. pH 791: between 10.0 and 11.5, in a solution (1 in 20). Loss on drying 731Dry it at 105 for 3 hours: it loses not more than 1.0% of its weight. Residue on ignition 281: not more than 0.1%. Heavy metals, Method II 231: 0.001%. AssayDissolve about 250 mg of Tromethamine, accurately weighed, in 100 mL of water, add bromocresol purple TS, and titrate with 0.1 N hydrochloric acid VS to a yellow endpoint. Each mL of 0.1 N hydrochloric acid is equivalent to 12.11 mg of C4H11NO3. Auxiliary InformationPlease check for your question in the FAQs before contacting USP.
USP35NF30 Page 4966 Pharmacopeial Forum: Volume No. 35(2) Page 316Chromatographic Column Chromatographic columns text is not derived from, and not part of, USP 35 or NF 30. |